Abstract The three peppers are commonly used as spices in our daily life.They are widely used in the field of cosmetics.The biological activities of their mainingredients are of great signifience for ourhealth.The origins of the three peppers as well as their other aspects are outlined.The structures,the relationship between the structures and spicy,the spicy mechanism,the function and the synthesis of the amide compoundswhich cause the spicyare introduced. It is expected that people can understand the cause of the spicy and its impacton health while enjoying the delicious food.