Abstract Argumentation teaching is a new inquiry teaching method that referenced argumentation skills in science research and has become one of the research focuses in international science education. There are several benefits to apply the teaching method in pre-service chemistry teacher education. It can improve pre-service teachers' understanding of nature of science, enhance their scientific reasoning ability, and help them learn how to implement it in the future. Strategies of argumentation teaching include the creation of open problem situation,integration of alternative conceptions and design of scoring rubric criteria.