An overview is provided about the development process of protein structure studies:from the early X-ray crystallography techniques to the modern cryo-electron microscopy techniques(cryo-EM),as well as the application of computational methods in protein structure prediction and design.Biomedical research has been not only advanced by these scientific achievements,but also a rich reservoir of pedagogical resources for chemistry education has been provided.By integrating these contents into chemistry teaching,students’ abilities can be effectively enhanced,their core competencies can be developed,and their interdisciplinary thinking can be cultivated.

The rich and diverse chemical components in food grant us unparalleled gustatory pleasures,yet we rarely recognize the potential hidden dangers.Alkaloids,a class of nitrogen-containing heterocyclic compounds that endow foods with unique flavors,can surprisingly act as“invisible killers”at the dining table.From the bitterness of sprouted potatoes and the delicacy of pufferfish liver to the richness of wild honey and the fragrance of fresh daylilies,these alkaloids in food resemble hidden“assassins”that imperceptibly threaten our health.The overview of toxic alkaloids in common foods,their unique chemical structures,mysterious toxicity mechanisms,intriguing synthesis pathways,and crucial preventive measures were introduced,aiming to help people savor culinary delights while avoiding potential health risks.

Based on knowledge graph and smart education concepts,a “knowledge graph+intelligent course” teaching mode for organic chemistry was constructed and implemented.This mode systematizes and visualizes scattered organic chemistry concepts and reaction mechanisms,forming a clear knowledge framework.During teaching implementation,student-teacher interaction was enhanced through intelligent course platforms and AI personalized recommendations,significantly improving students’ comprehensive abilities.As technology continues to advance,smart courses based on knowledge graphs will face multiple challenges,requiring stronger teacher training,introduction of emerging technologies,and construction of adaptive learning environments to effectively support students in confronting future challenges and achieving high-quality talent cultivation.

Energy conservation and carbon reduction in the chemical industry is an important strategy for achieving carbon neutrality.The key lies in improving the efficiency of the reaction process.Therefore,we need to deepen the understanding of reaction engineering more than ever before,guiding undergraduate students to understand the classical theory of reaction engineering based on“momentum,heat,and mass transfer with chemical reactions”,as well as the cutting-edge context of micro-nano scale in interdisciplinary backgrounds.Based on the background of deep integration of multidisciplinary in undergraduate education,this article proposes a classification teaching mode for chemical reaction engineering,focusing on teaching basic theory and engineering application knowledge based on different student groups,and practicing individualized teaching methods.Hopefully,this will provide new insights for the reform of chemical reaction engineering education.Addressing the complex multidisciplinary demands of carbon neutrality,this paper proposes a classified teaching mode featuring three tiers:foundational theoryengineering practicefrontier innovation.Through customized teaching strategies,this approach aligns chemical engineering education with carbon neutrality goals,providing a new paradigm for cultivating high-quality talent and advancing pedagogical reform.

Organic chemistry and biochemistry are two interrelated disciplines that have deep intersections in terms of material structure,reaction mechanism,and functional analysis.However,the two are relatively separated in the current Chinese education system,making it difficult for students to transfer knowledge between the two disciplines.Therefore,we proposed an“organic-biochemical”integrated teaching strategy,using the potential energy diagram as an example.By exploring the related descriptions of potential energy diagrams in both organic chemistry and biochemistry textbooks and extending this to a multidimensional potential energy surface model for extracurricular enrichment,we found the advantages of this strategy for student learning and teacher instruction.

It is crucial to help students construct a knowledge framework through logical relationships,forming a knowledge system that can be readily accessed and utilized.Taking the large-unit review of “Basic Quantum Mechanics-Atomic Structure-Diatomic Molecular Structure” in Structural Chemistry as an example,we guide students to structure the scattered knowledge they have acquired,aiding them in forming a framework of the subject.On one hand,the establishment of such a knowledge framework helps students organize their understanding,deepening their comprehension of the core concepts and content in structural chemistry.On the other hand,this systematic knowledge organization provides a well-structured and sufficient knowledge reserve for learning subsequent chapters.

In response to the key issues existing in inorganic chemistry course teaching,such as insufficient effectiveness of ideological and political education,weak ability for self-study,and weak cultivation of practical and innovative abilities,this study has constructed an innovative teaching path of “thought and politics guidance-digital intelligence drive-practice empowerment”:reconfiguring the course content to create a trinity ideological and political education system of “knowledge-ability-quality”;establishing a “two-line three-stage” digital intelligence teaching community based on smart platforms to activate classroom ecology;and building a progressive practical system of “literature reading-scheme design-experimental verification” to enhance practical innovative ability and scientific research literacy.

After completing the study of basic professional knowledge and experimental skills training,senior undergraduates majoring in applied chemistry are eager to understand the latest trends in cutting-edge technologies and enhance the practical application ability of their knowledge and skills to clarify their personal development directions.To meet this demand,the Department of Chemistry at Tianjin University offers an innovative experimental course for senior undergraduates.The course adopts a cultivation mode of“interest-oriented,group-based,category-divided,and stage-by-stage”,deeply integrating project-based teaching with experiential learning,which effectively improves students’ innovative awareness and practical abilities.It has made an instructive attempt in training chemistry talents and can serve as a reference for experimental teaching in other institutions.

In response to the challenges in the experimental teaching of carbon quantum dots synthesis,including substantial time consumption and a tenuous grasp of the microscopic mechanisms,a comprehensive teaching system integrating virtual simulation and entity experiment has been developed.Guided by outcomes-based education(OBE) and constructivism theory,a knowledge chain of“synthesis-regulation-application”is designed,and a closed-loop process of“theory-virtual-practice-application”forms through the teaching path of“virtual first,then real and complementary virtual-real”.The virtual module uses the 3D dynamic model and the energy level transition animation to visualize the microscopic formation mechanism,embeds the parameter optimization simulation process,introduces the parameter overrun warning and safe operation simulation to reduce the experimental risk.Conversely,the entity module centers on standardizing experimental operations,implementing detection techniques,exploring practical applications,and strengthening the students’ practical skills through the integration of data analysis and extended tasks.The results of the teaching implementation demonstrate a notable improvement in the experimental efficiency.Specifically,the experimental duration has been reduced by 56%,and the associated costs have been decreased by 75%.Students have exhibited a deeper comprehension of the underlying mechanisms and a stronger awareness of safety.The majority of students have successfully mastered the requisite knowledge and skills,with a subset demonstrating innovative thinking.The system realizes the deep integration of cutting-edge technology and teaching,providing a paradigm for the“three-high and three-difficult”experimental teaching reform,and exploring an innovative path of virtual-real integration for the training of new engineering talents.

In response to the gap between undergraduate organic chemistry experimental teaching programs and the rapid advancements in organic phosphorus chemistry,this study innovatively developed a“theory-synthesis-characterization-application”four-dimensional integrated experimental teaching model grounded in organic phosphorus chemistry.A new comprehensive experimental project titled“Synthesis and Application of Benzodiazepine Phosphine Oxide Flame Retardants”was independently designed,integrating fundamental organic phosphorus chemistry theory,green synthesis techniques,modern characterization methods,and practical fire safety applications.The reagents used are cost-effective and readily accessible,the procedures are safe and straightforward,the knowledge integration is extensive,and the content is highly adaptable for further exploration.This experiment not only deepens students’ understanding of organic phosphorus chemistry but also encourages them to propose innovative solutions to practical problems,thereby enhancing their ability to connect theoretical knowledge with real-world applications.The experiment has been successfully implemented in one cycle of undergraduate laboratory teaching,guiding students to secure one award in provincial-level or higher academic competitions.Furthermore,the diverse teaching methodologies employed in this project hold significant potential for broader application in other educational institutions.

To address the limitations of traditional physical chemistry experiments,which prioritize operational skills over critical thinking,this study developed a research-integrated teaching mode centered on the regulation of proton conductivity in metal-organic framework materials(MOF-808).The mode incorporates a four-stage task chain“literature review,experimental design,characterization analysis,and outcome presentation”and employs a semi-exploratory teaching method.Students,working in groups,were guided to refine scientific questions,optimize experimental parameters,and analyze structure-performance relationships.Teaching practices demonstrated significant improvements in students’ scientific thinking,experimental skills,and teamwork capabilities.A multi-dimensional evaluation system confirmed that this mode effectively transitions students from“procedural executors”to“innovative researchers”,offering a practical pathway for experimental teaching reform under the New Engineering Education framework.

Generative Artificial Intelligence(GAI) has become an important tool for innovating teaching methods and optimizing teaching practices in the field of education.Focusing on the course of instrumental analysis,this paper proposes a teaching practice path based on GAI,covering selection strategies,content generation,and evaluation effects,and explores its role in teaching.The results show that in the teaching activities,GAI can reconstruct the teaching content according to the requirements of professional teaching standards,optimize the teaching strategies,assist in the production of courseware,teaching videos,interactive web pages and other teaching resources,and carry out the analysis of learning conditions,which provides strong support for the digital transformation of curriculum education and the improvement of education and teaching quality.

To address prevalent issues in curricular instruction,such as the disconnect between theory and practice and the misalignment of course content with industry needs,this study explores effective pathways for integrating industry insights into drug synthesis reaction teaching.The research proposes a three-dimensional interactive teaching mode that combines case analysis,guidance from industry mentors,and on-site visits.This mode integrates cutting-edge technologies,innovative processes,and practices associated with digital transformation in the pharmaceutical industry directly into the classroom.As a result,it significantly improves both the relevance of the curriculum and students’ practical innovation capabilities.Taking the optimization project of the green process for a key intermediate of apalutamide as a typical case,it demonstrates a real scenario of collaboration between teachers and students with enterprises to tackle challenges.This not only cultivates students’ professional skills and innovative capabilities but also promotes the improvement of teaching standards among faculty.Additionally,it provides technical support to enterprises,ultimately contributing to the high-quality development of the pharmaceutical industry by supplying talent and technological reserves.This mode of deep integration between industry and education effectively facilitates the organic connection among the education chain,talent chain,industrial chain,and innovation chain,representing a beneficial practice for developing new quality productive forces in the pharmaceutical field.

In the new era of promoting socialist modernization,the role of graduate education in innovation and creation,and the training of high-level talents,has become increasingly prominent.Curriculum teaching holds a significant position in graduate education.Accelerating curriculum development and promoting teaching reforms are the primary tasks of graduate education in this new era.Against this backdrop,and with the goal of cultivating interdisciplinary innovative talents for the new era,this paper proposes reforms toInorganic Synthesis Chemistry course in terms of teaching content,instructional mode,teaching practices,and curriculum-based ideological and political education.The aim is to equip students with self-directed learning capabilities,innovative and creative abilities,as well as fundamental research thinking and literacy.

The VASP automated calculation tool,developed based on large language model,simplifies the generation of input files and the analysis of computational results.Applying the developed tool in electrochemical teaching can lower the threshold for software learning,and improve teaching efficiency.The natural language interaction function of the developed tool can enhance the flexibility and interactivity of teaching,and inspire students’ innovative thinking and interest.

Engineering education needs to adapt to the development demands of the intelligent era and accelerate its transformation from knowledge-oriented to problem-oriented.AI-enabled project-based teaching is a new teaching mode aimed at cultivating engineering capabilities.This mode empowers project practices through artificial intelligence technology,significantly enhancing students’ engineering practical abilities,innovative thinking,academic vision,learning efficiency,and personalized growth.Taking the course “Inorganic Chemistry and Engineering” as an example,this paper elaborately introduces the four stages of topic selection,mid-term,conclusion,and evaluation in the teaching design and implementation of the AI-enabled project-based teaching mode.It systematically explores how to utilize AI to empower project-based teaching and analyzes the advantages and disadvantages of this teaching mode empowered by AI.This has reference significance for enhancing students’ engineering capabilities and comprehensive qualities,cultivating outstanding engineering talents,and promoting the innovation of engineering education mode.

Ionones(including ionols) and damascenones(including damascones) are common monoterpenes widely found in many plants.They were widely used in food,daily chemicals,flavors and fragrances.Although the structures of these compounds are not particularly complicated,due to the similarity in structures and the complexity of the IUPAC nomenclature,there is a widespread confusion in both Chinese and English journals due to the lack of simplified naming method.Therefore,a method needs to be created to simplify the naming.This paper proposes a parent hydride ionane to simplify these compounds in a half-nomenclature way.The result is simple and intuitive,and it successfully solves the confusion and trouble in the naming of these compounds.

Chemistry is a fundamental discipline in natural science,serving not only as the theoretical cornerstone for constructing modern engineering systems,but also as a critical force to promote technology innovation and industry upgrading.In the field of national defense and military,the distinctiveness of chemistry discipline is particularly prominent.It is highly combined with various technologies and research of new materials related to national defense,which decides its strategic significance in cultivating military talents.Compared with other types of universities in China,the national-defense and military type colleges and universities possess unique industry attribution and talent education missions.Their chemistry education systems must place greater emphasis on practical application and defense engineering field.However,the current structure and teaching modes of chemistry education in the national-defense and military type colleges and universities still largely resemble those of general universities,without distinctive differentiation.Therefore,there is an urgent need to establish a dedicated education mode tailored to the specific requirements of defense-related engineering field.The engineer’s education system in France with its unique training mode and outstanding educational achievements enjoys a global reputation,which offers valuable experiences for countries worldwide to draw upon.Taking the École Supérieure de Physique et de Chimie Industrielles de la Ville de Paris(ESPCI Paris) as an example,this work delves into its educational characteristics,and systematically compare it with the chemical education of a typical Chinese national defense and military type university,Northwestern Polytechnical University,in terms of talent cultivation modes,curriculum offerings and practical teaching from engineering education system in France,which aims to provide beneficial references for the reform and development of high chemistry education in Chinese national defense and military type universities,thereby contributing to the cultivation of high-quality chemistry talents for national defense.