The lab-on-a-molecule probe can provide high spatial density of the induction signal in molecular-level, mainly divided into molecular logic gate, molecular multi-mode detection and the probe with both function. The probe has played an important role in the qualitative analysis of multi-analyte and the quantitative analysis in competitive sensitive detection. This paper summarizes the application of the above three types of probes in biochemical analysis (metal cations, inorganic anions, amino acids, proteins, and pathogens).

Taking organic chemistry, an important basic course for chemistry major in Central South University, as an example, this paper discusses the reform of open excellent model curriculum. In order to adapt to the rapid development of information technology and the characteristics of college students, this paper expounds the construction and practice of open excellent model courses from the aspects of innovative course teaching focus, innovative course teaching methods, and the teaching effect. Web-based autonomous learning, classroom interaction, experimental practice, scientific and reasonable diversified curriculum assessment, effectively improve students' interests and enthusiasm in learning, and get a good teaching effect.

In the present paper, the authors briefly discussed the main problems in current analytical chemistry teaching. And the authors proposed graphical method to solve many problems such as predominance distribution, resolution of end point error in complexometric titration, related calculations in oxidation-reduction titration, writing of proton balance equation, and calculation of precipitate solubility. Teaching practices revealed that graphical method had the advantages of generality, intuitiveness and brevity and it was an effective means in analytical chemistry teaching.

In order to find the reasons that the synthesis of adipic acid do not work well, we investigated four aspects, such as the optimization of dropping speed of cyclohexanol, the change of reaction temperature with reaction time, the effect of coagulation time on product quality and the volume of concentrated solution. According to the experimental results, we found the main reasons for experiment failure, and improved experiment device, selected the optimal process conditions:dropping speed of cyclohexanol at 20 s/drops, the coagulation time of 8 min, the concentrated volume solution of 20 mL. The success rate of the improved experiment was over 90% and the product had good quality.

This paper, taking JEM-2100PLUS as an example, describes the fundamental structure, control panels and imaging principle of TEM. The ultimate goal of using transmission electron microscopy is to get high quality photos, and therefore this paper mainly describes the operation of transmission electron microscopy, the method of getting high quality photos and the common troubleshooting.

The problems of less hours of experiment and limited availability of labs appeared with the modular teaching reform of chemistry experiment, which leads the students to fail to learn chemistry experiment courses systematically. "Virtual simulation experiment" was designed as a supplement in lab-based chemistry experiments in order to solve these problems, and the reform of chemistry experiments teaching mode based on "online+offline" was studied. The basic knowledge of experiment was learned by self-study on the line and consolidated through experimental training. The module experiment would be trained after watching video. Comprehensive experiment would be applied for laboratory operation after online self-study. Then the whole experiment teaching process was completed. The problems of less hours of experiment and limited availability of labs were solved. The aim of training the student's practical ability, independent thinking ability and innovative thinking ability has been achieved.

A comprehensive chemical experiment named synthesis and characterization of MCM-41 mesoporous silica material was designed. Experimental contents contain the preparation of MCM-41 mesoporous silica material, and its full characterization in structure and morphology including scanning electron microscopy, infrared spectroscopy, low angle X-ray diffraction and nitrogen adsorption-desorption measurement. This experiment can not only improve undergraduates' basic experimental skills, but also make them to comprehend the fundamentals of related chemical courses. Furthermore, the experiment may also arouse undergraduates' interests to explore the advances in chemistry.

This paper introduced an integrated experiment, preparation of magnetic metal organic framework and application to the adsorption of lead. Fe₃O₄ was firstly prepared, then amino groups were introduced to prepare the magnetic metal organic framework adsorbent. The adsorption of lead by the magnetic adsorbent was investigated coupled with flame atomic absorption spectroscopy. The present experiment covers adsorption kinetics in physical chemistry and flame atomic absorption spectroscopy in instrumental analysis, which can benefit students to learn such knowledge.

In this experiment, the direct aldol reaction between unmodified acetone and 4-nitrobenzaldehyde catalyzed by L-proline shows both high yield and moderate stereoselectivity. The mixture was stirred at room temperature over a period of 2 hours. The pure product was obtained by column chromatography on silica gel and the enantiomeric excess of the product was determined by chiral HPLC analysis. The product yields obtained by the students are about 53%~74%, and the values of ee are about 62%~69%. This comprehensive experiment can not only strengthen the basic synthetic skill and operation, but also broaden the knowledge and cultivating the ability of analyzing and solving problems.

In order to reflect the teaching effect of the flipped classroom through the optimization of the teaching design of the "Food Chemistry" course, based on combining the online learning model and the offline classroom teaching mode. The offline teaching and online learning are organically integrated, thus, the classroom incentives and process assessment programs were established. Through the comparison and questionnaire surveys before and after the reform, students' initiative, enthusiasm, and participation in online and offline classrooms have been significantly improved, and teaching reforms have achieved the desired results.

The patterns of internationalization of postgraduate education reform of chemical postgraduate education of Qingdao University's material discipline has been taken as a case study, and the effective strategies of internationalization of postgraduate education in chemistry was put forward out including two aspects, the large scale of talent flowing, and the internationalization of platform construction. Based on the domestic and international industry-researching institute-university educational cooperation and collaborative training platforms, a practical training platform, which is the in-depth integration and collaborative education of all-round industry, science and education at home and abroad, has built. A dynamic and virtuous knowledge industrial chain circulation, named "platform construction-discipline construction-talent cultivation-feedback improvement", has formed, feedback-management-evaluation organism in the industry-researching institute-university educational cooperation has been realized in the educational process of chemical postgraduate student, and it should be a popularized internationalizing reform model of chemical postgraduate education in the provincial institutions of higher learning throughout the country.

Based on the present situation of the practice teaching in remote education, we design four modules in analytical chemistry experiment teaching, including multimedia, video and virtual simulation laboratory and expansion experiments with the wide use of the combination of modern communication technology and education. Furthermore, this paper introduced the online platform design, organization and implementation, teaching quality assurance and evaluation of teaching effect, explored the application of virtual experiment teaching in distance education to satisfy the requirements of the development of experimental teaching in distance education, to build a good learning platform for the vast number of self-learners to learn skills.

Data obtained from two different equipment usually cannot match with each other. Therefore, data processing usually is needed before they can be plotted into one figure. The linear interpolation method is often used to solve this problem. However, it brings big errors and is exhausting and time consuming. In this paper, temperature and MS signal data from TPO-MS experiment was accurately and efficiently correlated by the layer and translation function of Origin software.

In order to investigate the water quality status in the lower reaches of the A and B River. Eight sampling points were selected in downstream of every river during 2014 high flow period (August) and low water season (December). DO, NH₄⁺-N and other four physiological indexes were detected. Meanwhile, the Hg, Pb and other five heavy metal indicators were also detected. In addition, single parameter evaluation method and water quality identification index method were used to analyze the water quality status of two rivers while logarithmic power function universal exponential formula was used to evaluate eutrophic state of two rivers. Results showed that the water qualities of downstream were dominated by the inferior fifth class of two rivers. All kinds of heavy metals were not exceeding standard and the main excessive amounts of pollutant were TN, TP, NH₄⁺-N and so on. The water quality of the A river was better than B river. Water quality in high flow period was superior to that in dry season. What's more, water qualities in lower reaches of two rivers were in a state of rich and high trophic. It is necessary to intensify efforts to curb pollution in agricultural areas of two rivers in order to reduce the risk of eutrophication of the A and B River.

According to the year and the content, we analyzed the situation of the publication of information technology used in chemistry teaching in the Journal of Chemical Education in USA from 2012 to 2018, and introduced 4 main examples of representative values, summarizing the current status and trends of international chemical education research.